Ocular inflammation: What is the role of biologic agents in treatment?

The term ocular inflammation or uveitis describes the inflammation of the middle layer of the eye (between the retina and the outer layer). This layer is called the uveal and is rich in blood vessels which transport blood to and from the eye. Uveitis may cause very serious vision problems.

Causes and symptoms of ocular inflammation

The causes of ocular inflammation are often unspecified. However, factors such as injuries, viruses, infection, systemic diseases, fungi or parasites can lead to this dangerous eye condition. For a large percentage of patients it is a manifestation of an autoimmune disease.

The main symptoms of uveitis are eye redness, blurred vision, pain and light sensitivity. Usually the symptoms occur suddenly and may affect either one or both eyes.

If not treated early it may lead to even more serious conditions such as glaucoma, cataract, and retinal damage. In fact, it is the fifth cause of blindness in the developed countries.

How is ocular inflammation treated?

To treat uveitis, aside from cortisone, injectable biologic agents are now used, targeted towards blocking TNF-α, which is a cause of inflammation.

Scientific Director: Maselos Stelios Ophthalmic Surgeon